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Predictive Factors of De Novo Overactive Bladder After Radical Prostatectomy in Patients With Clinically Localized Prostate Cancer: A Prospective Observational Study
Journal of Urologic Oncology 2021³â 19±Ç 2È£ p.109 ~ p.116
ÀÌÁسç(Lee Jun-Nyung) - Kyungpook National University School of Medicine Department of Urology
±è»ó¿ø(Kim Sang-Won) - Kyungpook National University School of Medicine Department of Urology
º¯°æÇö(Byeon Kyeong-Hyeon) - Kyungpook National University School of Medicine Department of Urology
Á¤Àç¿í(Chung Jae-Wook) - Kyungpook National University School of Medicine Department of Urology
ÇÏÀ±¼®(Ha Yun-Sok) - Kyungpook National University School of Medicine Department of Urology
ÃÖ¼®È¯(Choi Seock-Hwan) - Kyungpook National University School of Medicine Department of Urology
±è¹ü¼ö(Kim Bum-Soo) - Kyungpook National University School of Medicine Department of Urology
±èÇöÅÂ(Kim Hyun-Tae) - Kyungpook National University School of Medicine Department of Urology
±èÅÂȯ(Kim Tae-Hwan) - Kyungpook National University School of Medicine Department of Urology
À¯Àº»ó(Yoo Eun-Sang) - Kyungpook National University School of Medicine Department of Urology
±ÇűÕ(Kwon Tae-Gyun) - Kyungpook National University School of Medicine Department of Urology
Abstract
Purpose: To evaluate the incidence of de novo overactive bladder (OAB) and the factors related to its occurrence following radical prostatectomy (RP) in patients with clinically localized prostate cancer (PCa).
Materials and Methods: We prospectively examined 50 patients without OAB who underwent RP for clinically localized PCa in our institution from August 2019 to February 2020. We performed assessments using the International Prostate Symptom Score (IPSS), the Overactive Bladder Symptom Score (OABSS), and uroflowmetry before surgery and 3 months after RP. OAB was defined as a score of 1 or more on the urgency components of the OABSS. Three months after RP, the patients were divided into 2 groups based on the presence of de novo OAB symptoms.
We evaluated the patients¡¯ demographics and outcomes after RP according to their de novo OAB grouping. The predictive factors of de novo OAB after RP were analyzed using a multivariate logistic regression model.
Results: Of the 50 patients, 22 (44%) had de novo OAB 3 months after RP. The patients in the de novo OAB group were older, had higher preoperative IPSS storage subscores, and had larger volumes of postvoid residual urine on preoperative uroflowmetry than those in the non-de novo OAB group. Multivariate analysis showed that age and preoperative IPSS storage subscores were predictive factors of de novo OAB after RP.
Conclusions: De novo OAB was observed in 44% of the patients 3 months after RP. Age and preoperative IPSS storage subscores were predictive factors of de novo OAB following RP.
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Prostate cancer, Prostatectomy, Overactive urinary bladder
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À¯È¿¼º°á°ú(Recomendation)
This study observed a considerable incidence rate (44%) of de novo OAB 3 months after RP in patients with clinically localized PCa.